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Elderly patients: Even with the biochemical details still unexplained, it is quite certain that the mitigating effect of Tramadol has mu-receptors as its main leverage.
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There are many reasons why a person can be anxious. Paradoxical reactions are the opposite effect of what the drug is supposed to be doing, such as increased irritability, anxiety, agitation, and poor sleep. The onset and peak of analgesia occur within 1 and hours, respectively, after oral administration of tramadol hydrochloride conventional tablets; peak plasma concentrations of racemic tramadol and its O -desmethyl metabolite M1 are achieved about 2 and 3 hours, respectively, after oral administration, corresponding to the time of peak analgesic effect.
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